The legendary British singer and his husband, David Furnish, have two children born to the same surrogate mother.
"How dare you refer to my beautiful children as 'synthetic,'" Elton John posted on Instagram on Sunday.
"Your archaic thinking is out of step with the times, just like your fashions. I shall never wear Dolce and Gabbana ever again," he continued, adding the hashtag #BoycottDolceGabbana.
The row began after Domenico Dolce and Stefano Gabbana, who are both gay and once were a couple, told the Italian magazine Panorama that IVF babies are "synthetic" and rejected surrogate mothers as "rented wombs".
The fashion duo went on to say they were opposed to gay couples adopting and that they only believed in traditional families.
"I'm gay, I cannot have children. I guess you can't have everything in life," Dolce said.
"Life has a natural course, there are things that can not be changed - and one of them is the family."
