The Chelsea manager had some choice words for his Arsenal rival, calling him a 'specialist in failure.'
The pair have never seen eye to eye, with Mourinho once quipping that the Frenchman was a 'voyeur'.
War of words: Chelsea boss Jose Mourinho has called Arsene Wenger a 'specialist in failure'
Target: Mourinho said he would not 'come back to London' if he had not won a trophy in eight years like Wenger
SAMI MOKBEL'S REACTION
Wow.
In all my years of sports reporting that was by far the most explosive
press conference I've been to... and I covered Crystal Palace when Neil
Warnock was in charge.
No holds barred from the Special One. Pure gold from Mourinho.
No holds barred from the Special One. Pure gold from Mourinho.
Mourinho has repeatedly talked down Chelsea's chances of winning the title, though they are currently top of the Premier League, describing his team as a 'little horse' and third favourites in the title race.
'Wenger is a specialist in failure. I'm not,' said Mourinho at his Friday press conference.
'If he is right it is because I don't fail many times. Eight years without a trophy is failure.
Feud: The two managers have a long history of mind games and harsh words
Rivals: Mourinho once accused Wenger of being a 'voyeur'
'The reality is he is a specialist. Eight years without a piece of silverware, that's failure. If that was me I would not come back to London. I'm not fearing anything in football.'
Pundits speaking on Twitter thought Mourinho may have over stepped the mark with his comments.
Gary Linekar said Mourinho was 'out of order', while Gary Neville asked if anyone was going to 'take him [Mourinho] on' at his mind games.
Chelsea travel to the Etihad to face Manchester City on Saturday in the FA Cup. First choice center back pairing John Terry and Gary Cahill are both missing for the Blues, but Manuel Pellegrini will welcome back Samir Nasri and Javi Garcia to his team.
Speaking yesterday in an exclsuive interview with Sportsmail, Mourinho said that the Premier League was now a 'four horse race' with Liverpool serious contenders.
However the Portuguese only allowed his praise to last for so long, before he claimed that Brendan Rodgers has an advantage because his team do not have to play in the Champions League.
‘If Brendan has a chihuahua it is one that trains a lot and rests a lot. The other dogs, they don’t train a lot because they play a lot and they don’t rest because they play every three days.
‘And when the Barclays Premier League goes to the crucial point, we all will have to play Champions League at the same time.
‘To play, for example, like we are going to do in Istanbul against Galatasaray on the Wednesday, Fulham on the Saturday.
‘Brendan’s chihuahua doesn’t do that. During the week it sleeps, eats and trains a little bit. So I have to say his chihuahua is a privileged one. Next season he will see what it is like to play in two, three, four competitions. This season he has this privilege which gives him a big advantage.’
Return: Samir Nasri (right) will return to action for Manchester City against Chelsea
Title contenders: Mourinho also claimed that Liverpool are in the title race as they don't have to play in the Champions League