The chat-show queen and sometime actress stepped out at the Los Angeles premiere of Lee Daniels' The Butler on Monday night - in which she takes on her first major movie role since the 1998 flop Beloved.
Oprah ensured she was a talking point in the bright dress which she teamed with pewter peep toe pumps and hooped earrings.
She embraced co-star Forest on the red carpet, hugging him and holding his hands for photographs.
Their co-star Minka Kelly, who plays Jacqueline Kennedy in the film, opted for a bright red dress, black high heels and a half beehive style updo.
Making an arrival: You know when the legendary Oprah Winfrey is in town
Suits you: Oprah carries off the brightest of bright pink dresses with aplomb
She joined co-star James Marsden, who plays President John F Kennedy, in signing autographs for fans waiting on the street outside the Regency Theatre in the Westwood area of Los Angeles.
Cast members Cuba Gooding Jr and Jane Fonda, who plays Nancy Raegan also arrived at the screening, with Fonda sporting a beige trouser suit and matching shoes.
In the movie, Forest Whitaker portrays the butler Cecil Gaines and Winfrey his wife Gloria in a story inspired by the life of Eugene Allen, a White House butler who served eight different US presidents.
Embraceable you: Oprah hugged Forest before the screening
Oprah, 59, took some persuasion to take the role, according to director Lee Daniels in an interview with The Daily Beast.
He said: 'She auditioned - but I begged and pleaded with her to. David [Oyelowo] was on board first, and he didn’t have to audition, and then Oprah came in to do a reading with Forest.
'I knew immediately that the chemistry was a Molotov cocktail. Magic. They read the birthday scene where they find out that their son Charlie is dead. And it took me about seven or eight months to convince her to take the part.'
Give us a twirl: Minka Kelly, who plays Jackie Kennedy, looks cute as a button in this pretty, red dress
Iconic role: Minka plays Jacqueline Kennedy in The Butler
The two first ladies: MInka Kelley and Jane Fonda cross generations
Oprah's reluctance to accept the role was due to fear she would embarrass herself after being stung badly following the failure of Beloved, she told the New York Daily News.
This crisis of confidence came despite winning an Oscar nomination for her acting debut in The Color Purple in 1985.
'I mourned that [Beloved] for a long time, she told the paper. 'I went into - I wouldn't say severe depression, but I could tell that this sadness I was feeling had sort of taken me over.
'I felt like I was behind a veil. I had literally said to myself, "If I am depressed, who am I going to talk to?"'
The newly-weds: Jimmy Kimmel and his new wife Molly McNearney attend the star-studded opening night at the Regal Cinema
More famous faces: actor Cuba Gooding Jr - here with his wife Sara Kapfer - is also on the castlist
Stellar cast: Bold in blue: Actress and
comedienne Kym Whitley joins a host of stars at the premiere on Monday
night, while singer, dancer and actor Elijah Kelley plays Charlie Gaines
The TV icon bounced back but the experience put her off the idea of acting again.
And when The Butler role came knocking she said: 'It did scare me very much.I said to [Lee Daniels], "I just don't want to embarrass myself".' Lee said, "You won't. Trust me!" I said it was me I have to trust.
'When you have a big, big so-called failure such as that, you have to look at it for what it can teach you.
'How can it grow you up so that you don't have to go through that kind of suffering again? It doesn't mean you won't have it again, but that - that impact - cannot happen again.'
Star of the show: Forest penned his signature for the dozens of waiting fans