The 42-year-old actor and 38-year-old rapper, real name Curtis Jackson, seemed oblivious to all others on Monday at the New York City premiere of 2 Guns.
Just ask Wahlberg's 35-year-old gorgeous fashion model wife, Rhea Durman.
Mark and 50 Cent were practically cheek-to-cheek while posing for photographs, while beautiful Rhea was a little further apart from her hubby.
The two tight friends also posed for pictures together on the red carpet for Mark's new drama with Denzel Washington.
The buddies clasped hands amid the clamor with 50 Cent sporting a particularly wide and toothy grin.
Three's a crowd? Mark and 50 Cent nearly posed cheek-to-cheek
Mark also looked pleased as could be as 50 Cent draped an arm across his shoulders.
Though it seems odd that a Boston native like Wahlberg and a tough rapper from New York would be good friends, these two are practically brothers.
50 Cent stood by Mark's side in April when bombs exploded at the Boston Marathon during a film screening later that night in New York City.
Both men looked united and somber as they stood side-by-side with left fists clenched and staring into the camera in solidarity with Mark's hometown.
Mark also of course posed for pictures with his stunning wife and the mother of his four children, Rhea.
The 35-year-old looked stunning in a simple floor length white gown featuring cap sleeves and a thin black belt.
Mark stars in 2 Guns, an action drama by director Baltasar Kormákur that follows a DEA agent and a naval intelligence officer who find themselves on the run after a failed attempt to infiltrate a drug cartel.
The movie opens Friday.
Dude, where's your bro? 50 Cent looked a little bummed without his buddy Marky Mark
Movie star: Wahlberg stars alongside Denzel Washington in 2 Guns opening on Friday
Happy couple: Mark and Rhea, married in 2009, also posed together at the event
Like brothers: Mark and 50 Cent, shown in April
at a New York City film screening, supported each other hours after the
Boston Marathon bombing