This time Leto, who rose to fame in the mid '90s, is almost completely unrecognisable on the cover of Candy magazine's sixth issue.
In fact, he looks a whole lot like singer Katy Perry or even actress Zooey Deschanel, with those blunt bangs, huge blue eyes and long lashes.
Leto plays a transsexual with AIDS in the upcoming movie "The Dallas Buyers Club" alongside Matthew McConaughey.
The 41-year-old actor lost an alarming amount of weight for the role, just like McConaughey famously did.